The alpha-casein peptide fragment (90-96) Arg-Tyr-Leu-Gly-Tyr-Leu-Glu,
one of the exorphins called ''food hormones'', is an efficient ligand
for Cu-II ions. Potentiometric and spectroscopic studies on aqueous s
olutions indicate that, depending on the pH range, complex species wit
h different coordination modes (involving the amino and the deprotonat
ed amide groups) are formed. The phenolate side chain of the Tyr resid
ue is not involved in the metal coordination.