METABOLIC STUDY OF ISOPROTURON IN GOATS FOLLOWING A SINGLE ORAL-ADMINISTRATION - TOXICOKINETICS AND RECOVERY

Toxicokinetic behavior and recoveries of isoproturon from feces, urine , and different tissues of goat were determined after 4, 5, 6, and 7 d ays following single oral administration at 500 mg/kg. Isoproturon was rapidly absorbed and attained blood concentration within 15 min of ad ministration. The kinetic behavior followed a two-compartment open mod el. The higher t(1/2)(beta) (9.78 +/- 0.33 h) and V-darea (4.49 +/- 0. 41 L/kg) associated with lower Cl-B (0.32 +/- 0.02 L/kg/h) suggested s low elimination from the blood. Approximately 56% of the total adminis tered compound was recovered from feces. The rate of excretion of isop roturon through feces was maximum at 48 h and could not be detected be yond 120 h. The excretion pattern of isoproturon through urine resembl ed that of feces, and approximately 10-11% was eliminated in urine. A maximum quantity of residue was detected in all tissues of goats slaug htered after 4 days followed by a substantial decline after day 5, and nothing could be detected after day 7. Histopathological study reveal ed that isoproturon produced moderate cellular changes like fatty dege neration in the liver and kidney and emphysema in the lung after 7 day s post administration.