G. Fronza et al., NATURAL-ABUNDANCE H-2 NUCLEAR-MAGNETIC-RESONANCE STUDY OF THE ORIGIN OF RASPBERRY KETONE, Journal of agricultural and food chemistry, 46(1), 1998, pp. 248-254
The site-specific natural abundance deuterium distribution of raspberr
y ketone 3 obtained through a variety of methods has been determined t
hrough H-2 NMR spectroscopy. This technique provided a means of distin
guishing between ''natural'' raspberry ketones biogenerated from 4-hyd
roxybenzalacetone (2), obtained from 4-hydroxybenzaldehyde of extracti
ve botanical origin and acetone produced by sugar fermentation by redu
ction using baker's yeast and other microorganisms, and other raspberr
y ketone samples obtained in different ''non-natural'' ways. Of natura
l origin is also a commercial sample obtained in an unspecified manner
. A mechanistic interpretation has been proposed to explain the differ
ence of site-specific deuterium content between the examined samples.