E. Rammer et F. Friedrich, THE EFFECTIVENESS OF INTRAUTERINE INSEMINATION IN COUPLES WITH STERILITY DUE TO MALE-INFERTILITY WITH AND WITHOUT A WOMANS HORMONE FACTOR, Fertility and sterility, 69(1), 1998, pp. 31-36
Objective: To examine the efficacy of IUI on fecundity and baby-take-h
ome rates in cases of infertility attributable to a male factor with a
nd without a woman's hormone factor, Design: Retrospective analysis. S
etting: Department of Gynecology and Obstetrics at the General Public
Hospital, Horn, Austria. Patient(s): Seventy-eight long-standing invol
untarily childless couples, Intervention(s): After a follicular phase
GnRH analog (buserelin) protocol with hMG stimulation of the woman and
a Percoll gradient preparation and capacitation of the man's semen, a
n IUI was performed, Main Outcome Measure(s): Fecundity and baby-take-
home rates, Result(s): One hundred nine inseminations were followed by
53 pregnancies (48.6%; 95% confidence intervals (CI) 38.9%-58.4%) and
38 deliveries (34.9%; 95% CI 26.0%-44.6%), Forty-nine children were b
orn and 47 are alive (43.1%), Conclusion(s): Intrauterine insemination
combined with buserelin gonadotropin stimulation, Percoll semen prepa
ration, and sperm capacitation is a feasible solution to the problem o
f sterility attributable to a male factor with and without a woman's h
ormone factor. (C) 1998 by American Society for Reproductive Medicine.