THE VALIDITY OF THE TEST OF INDIVIDUAL EQUIVALENCE RATIOS

We evaluate the validity of the test of individual equivalence ratios (TIER), a term coined by Anderson & Hauck (1990). The test was also pr oposed in Wellek (1989), It is proved to be a valid test under a class of unimodal symmetric distributions; this includes normal distributio ns. Since most bioequivalence studies involve data which are normal, o r at least unimodal and symmetric, the test is typically valid. It is, however, not always valid, as shown by counter examples.