PRENATAL-DIAGNOSIS OF TRISOMY-18 AT THE 10-14 WEEK ULTRASOUND SCAN

Authors
SHEROD C SEBIRE NJ SOARES W SNIJDERS RJM NICOLAIDES KH
Citation
C. Sherod et al., PRENATAL-DIAGNOSIS OF TRISOMY-18 AT THE 10-14 WEEK ULTRASOUND SCAN, Ultrasound in obstetrics & gynecology, 10(6), 1997, pp. 387-390
Citations number
16
Journal title
Ultrasound in obstetrics & gynecology → ACNP
ISSN journal
09607692
Volume
10
Issue
6
Year of publication
1997
Pages
387 - 390
Database
ISI
SICI code
0960-7692(1997)10:6<387:POTAT1>2.0.ZU;2-K
Abstract
A beneficial consequence of screening for trisomy 21 by a combination of maternal age and fetal nuchal translucency thickness (NT) at 10-14 weeks is the early diagnosis of trisomy 18. In a multicenter study of 91 091 singleton pregnancies there were 106 fetuses with trisomy 18 an d 83% were identified by NT screening. Trisomy 18 was also associated with early onset intrauterine growth retardation, decreased fetal hear t rate and the presence of exomphalos.