EFFICIENT LARGE-SCALE SYNTHESIS OF 4-PHENYL-3-BUTYN-2-ONE, A KEY INTERMEDIATE FOR A NOVEL POTENT ADENOSINE ANTAGONIST

Authors
ZANKA A
Citation
A. Zanka, EFFICIENT LARGE-SCALE SYNTHESIS OF 4-PHENYL-3-BUTYN-2-ONE, A KEY INTERMEDIATE FOR A NOVEL POTENT ADENOSINE ANTAGONIST, Organic process research & development, 2(1), 1998, pp. 60-62
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Organic process research & development → ACNP
ISSN journal
10836160
Volume
2
Issue
1
Year of publication
1998
Pages
60 - 62
Database
ISI
SICI code
1083-6160(1998)2:1<60:ELSO4A>2.0.ZU;2-3
Abstract
Phenylacetylenic Grignard reagent reacts with acetic anhydride under m ild conditions to give 4-phenyl-3-butyn-2-one in high yield. This meth od was applicable to a large-scale synthesis, and optimized reaction c onditions have been investigated.