Rr. Allison et al., TIN ETHYL ETIOPURPURIN-INDUCED PHOTODYNAMIC THERAPY FOR THE TREATMENTOF HUMAN IMMUNODEFICIENCY VIRUS-ASSOCIATED KAPOSIS-SARCOMA, Current therapeutic research, 59(1), 1998, pp. 23-27
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
Current local treatments for cutaneous human immunodeficiency virus-as
sociated Kaposi's sarcoma lesions can be less than ideal. Photodynamic
therapy (PDT) consisting of a photoreactive drug and a laser light so
urce has been used to treat a variety of neoplasms. This paper present
s the case report of a 36-year-old man with multiple Kaposi's sarcoma
lesions. Using the photosensitizer tin ethyl etiopurpurin and red ligh
t activation 24 hours postinfusion, we achieved excellent subjective a
nd objective response on follow-up examinations to 20 weeks posttreatm
ent. Photodynamic therapy is an outpatient procedure that is well tole
rated and highly effective for the treatment of Kaposi's sarcoma lesio
ns. It offers the distinct benefit of effective destruction of multipl
e lesions in a single session without severe morbidity. PDT should be
considered as the first-line treatment of Kaposi's sarcoma, but it als
o should undergo large clinical trials to fully assess its capabilitie
s.