S-ARYL CYSTEINE S,S-DIOXIDES AS INHIBITORS OF MAMMALIAN KYNURENINASE

Authors
DRYSDALE MJ REINHARD JF
Citation
Mj. Drysdale et Jf. Reinhard, S-ARYL CYSTEINE S,S-DIOXIDES AS INHIBITORS OF MAMMALIAN KYNURENINASE, Bioorganic & medicinal chemistry letters, 8(2), 1998, pp. 133-138
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
2
Year of publication
1998
Pages
133 - 138
Database
ISI
SICI code
0960-894X(1998)8:2<133:SCSAIO>2.0.ZU;2-R
Abstract
A series of 2-amino-S-aryl cysteine S,S-dioxides have been synthesised and shown to inhibit kynureninase an important enzyme in the biosynth esis of the known excitotoxic moiety quinolinic acid. The most potent of these, 2-amino-5-methyl-S-phenyl cysteine S,S-dioxide 6d, inhibits interferon-gamma induced synthesis of quinolinic acid in human macroph ages. (C) 1998 Elsevier Science Ltd. All rights reserved.