ALANYL-PNA HOMODUPLEX - A-T PAIRING WITH THE N7-REGIOISOMER OF ADENINE

Authors
DIEDERICHSEN U
Citation
U. Diederichsen, ALANYL-PNA HOMODUPLEX - A-T PAIRING WITH THE N7-REGIOISOMER OF ADENINE, Bioorganic & medicinal chemistry letters, 8(2), 1998, pp. 165-168
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
2
Year of publication
1998
Pages
165 - 168
Database
ISI
SICI code
0960-894X(1998)8:2<165:AH-APW>2.0.ZU;2-H
Abstract
The N7-regioisomer of adeninyl alanine can be used as a building block for the synthesis of alanyl-PNA. By changing the nucleobase connectiv ity from N9 to N7, pairing with the Hoogsteen side is no longer possib le and the order of donor/acceptor positions at the Watson-Crick side is reversed. This influences the pairing selectivity but not the stabi lity of alanyl-PNA self-pairing complexes, as shown by UV and CD spect roscopy. (C) 1998 Elsevier Science Ltd. All rights reserved.