QUATERNARY SUBSTITUTED PDE4 INHIBITORS I - THE SYNTHESIS AND IN-VITROEVALUATION OF A NOVEL SERIES OF OXINDOLES

Authors
HULME C POLI GB HUANG FC SOUNESS JE DJURIC SW
Citation
C. Hulme et al., QUATERNARY SUBSTITUTED PDE4 INHIBITORS I - THE SYNTHESIS AND IN-VITROEVALUATION OF A NOVEL SERIES OF OXINDOLES, Bioorganic & medicinal chemistry letters, 8(2), 1998, pp. 175-178
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
2
Year of publication
1998
Pages
175 - 178
Database
ISI
SICI code
0960-894X(1998)8:2<175:QSPII->2.0.ZU;2-L
Abstract
The following letter presents the synthesis and in vitro evaluation of a novel quaternary substituted series of phosphodiesterase type (IV) (PDE4) inhibitors. The compounds represent conformationally constraine d analogues of the Celltech PDE IV inhibitor, CDP 840. Examples with s ub-micromolar IC50's for PDE4 inhibition are reported. (C) 1998 Elsevi er Science Ltd. All rights reserved.