SYNTHESIS AND IMMOBILIZATION OF CERAMIDE ANALOGS ON SILICA PARTICLES

Authors
YIN JM LIU HL PIDGEON C
Citation
Jm. Yin et al., SYNTHESIS AND IMMOBILIZATION OF CERAMIDE ANALOGS ON SILICA PARTICLES, Bioorganic & medicinal chemistry letters, 8(2), 1998, pp. 179-182
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
2
Year of publication
1998
Pages
179 - 182
Database
ISI
SICI code
0960-894X(1998)8:2<179:SAIOCA>2.0.ZU;2-V
Abstract
Ceramides are the major lipid components of the stratum corneum, the m ajor permeability barrier of the skin. Here we report a chemical synth esis of ceramide analogs covalently bonded on the silica particles, th at can be used to predict the skin permeability of chemicals via HPLC methods. (C) 1998 Elsevier Science Ltd. All rights reserved.