SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW FLOSULIDE ANALOGS, SYNTHESIZED FROM NATURAL SAFROLE

Authors
LAGES AS SILVA KCM MIRANDA ALP FRAGA CAM BARREIRO EJ
Citation
As. Lages et al., SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW FLOSULIDE ANALOGS, SYNTHESIZED FROM NATURAL SAFROLE, Bioorganic & medicinal chemistry letters, 8(2), 1998, pp. 183-188
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
2
Year of publication
1998
Pages
183 - 188
Database
ISI
SICI code
0960-894X(1998)8:2<183:SAPEON>2.0.ZU;2-6
Abstract
Four new aryl-sulfonamide derivatives (3a, 4a, 5a similar to b), havin g methylenedioxy group attached to phenyl ring, were prepared from nat ural safrole and evaluated as anti-inflammatory agents. The (N) under bar-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at th e same molar concentration, in carrageenan-induced pleurisy assay. (C) 1998 Elsevier Science Ltd. All rights reserved.