NEW TAXANES AS HIGHLY EFFICIENT REVERSAL AGENTS FOR MULTIDRUG-RESISTANCE IN CANCER-CELLS

Authors
OJIMA I BOUNAUD PY TAKEUCHI C PERA P BERNACKI RJ
Citation
I. Ojima et al., NEW TAXANES AS HIGHLY EFFICIENT REVERSAL AGENTS FOR MULTIDRUG-RESISTANCE IN CANCER-CELLS, Bioorganic & medicinal chemistry letters, 8(2), 1998, pp. 189-194
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
2
Year of publication
1998
Pages
189 - 194
Database
ISI
SICI code
0960-894X(1998)8:2<189:NTAHER>2.0.ZU;2-Q
Abstract
New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal act ivity (less than or equal to 99.8%) against drug-resistant human breas t cancer cells when co-administered with paclitaxel or doxorubicin. Th is activity is ascribed to the highly efficient blocking of P-glycopro tein efflux by these new taxanes. (C) 1998 Elsevier Science Ltd. All r ights reserved.