SYNTHESIS, STRUCTURAL CHARACTERIZATION AND BIOLOGICAL SCREENING OF MANGANESE(II) COMPLEXES OF S O AND N DONOR AGENTS/

Manganese(II) complexes of biologically potent ligands hydrazinecarbox amide (HSCZ) or -carbothioamide (HTSCZ) have been prepared. These are of the type [MnCl(NX)H2O] and [Mn(NX)(2)] (X is O or S and NX = donor system). Elemental analyses, molecular weight determinations, molar co nductance, magnetic moment, electronic, IR and ESR spectral studies ha ve been employed to characterize these complexes. Magnetic data show t hat the ground state of these compounds is the expected high spin stat e and the spectral data suggest that the coordination of the ligand to the central metal atom takes place in a monobasic bidentate fashion t hrough the thiolo sulphur or hydroxo oxygen and azomethine nitrogen. T he representative free ligands and their respective metal complexes we re tested in vitro against different microorganisms to assess their an timicrobial properties.