A TRIAL OF REDUCING ADHESION FORMATION IN A UTERINE HORN MODEL

For the prevention of postoperative adhesion formation, one of the mos t common causes of infertility, none of the adjuvants had been proven uniformly effective. In this study we evaluated the effectiveness of s odium carboxymethylcellulose (SCMC) and disodium cromoglycate (DSCG) i n postoperative adhesion prevention in a rat uterine horn model. Thirt y female Sprague-Dawley rats were used. After uterine horn abrasion, i n 10 rats 10 mi 0.9% saline, in 10 rats 10 ml of 2% SCMC, and in 10 ra ts 10 mi DSCG were administered intraperitoneally. Two weeks later, al l animals were sacrificed and adhesion formation was assessed. All the pieces of the peritoneum biopsies were stained with Luna's mast cell stain to assess the mast cell degranulation. The mean adhesion scores were 2.1, 2.0 and 1.5 for saline, SCMC and DSCG groups respectively. T here were no significant differences among all groups. In the patholog ic examination, mast cell degranulation was less in the DSCG group tha n the other groups.