RELATIONSHIP BETWEEN FECAL BILE-ACIDS AND THE OCCURRENCE OF COLORECTAL NEOPLASIA IN EXPERIMENTAL MURINE ULCERATIVE-COLITIS

Objective: The possible role of fecal bile acids in colorectal carcino genesis in ulcerative colitis has been reported. In this study, we inv estigated the relationship between fecal bile acids and the occurrence of colorectal neoplasia in experimental murine colitis induced by dex tran sulfate sodium. Methods: Colorectal neoplasia in experimental col itis was induced by dextran sulfate sodium subsequent to a single azox ymethane pretreatment. Fecal bile acids were analyzed by gas-liquid ch romatography, Results: Multiple high-grade dysplasias (intramucosal ad enocarcinoma) and inflammatory changes were seen in all mice administe red dextran sulfate sodium and azoxymethane. Inflammatory changes were also observed in all mice given dextran sulfate sodium only, while ne ither tumor nor inflammatory changes were detected in any of the contr ol mice. Significant increases in cholic acid were observed in the mic e of the colorectal tumor and experimental colitis groups during the e xperimental period, while in the control mice, no significant changes in fecal bile acids were obseved. Conclusion: It is suggested that fec al cholic acid and colitis may be intimately related to the developmen t of colorectal neoplasia in this experimental model of murine colitis as well as in ulcerative colitis.