HOLT-ORAM-SYNDROME AND MULTIPLE VENTRICULAR SEPTAL-DEFECTS - AN ASSOCIATION SUGGESTING A POSSIBLE GENETIC-MARKER

A family is described where the father has the many skeletal, but none of the cardiac abnormalities associated with the Holt-Gram syndrome. His two daughters have similar skeletal anomalies, but with identical cardiac lesions, as does another patient, raising the possibility oi a n associated genetic marker.