ADENOID BASAL CARCINOMA OF THE UTERINE CERVIX, DETECTION OF INTEGRATED HUMAN-PAPILLOMAVIRUS IN A RARE TUMOR OF PUTATIVE RESERVE CELL ORIGIN

This study investigated the role of human papillomavirus (HPV) in aden oid basal carcinoma, a rare neoplasm of the uterine cervix. Nine archi val paraffin embedded tumors were analyzed with non-isotopic in situ h ybridization (NISH) for HPV types 6, 11, 16, 18, 31, and 33 using digo xigenin-labelled probes. The polymerase chain reaction (PCR) was perfo rmed on each of the cases using E6 consensus primers to HPV. A total o f 67% of adenoid basal carcinomas harbored the HPV genome with NISH, o f which 3 were PCR-positive. Integrated KPV 16 DNA was demonstrated in 4 of the 6 NISH positive cases. Two cases showed integrated HPV 33. H PV DNA was not detected in the three remaining cases. These results sh ow that the integrated high-risk HPV, in particular type 16, is associ ated with this uncommon cervical tumor.