PRIMARY ENDOCERVICAL EXTRAOSSEOUS EWINGS SARCOMA PNET/

A 36-year-old woman presented with intermenstrual spotting and was fou nd to have a cystic mass involving the uterine cervix on a pelvic ultr asound examination. A necrotic and hemorragic tumor was excised by hys terectomy and processed for light and electron microscopic investigati on and molecular analysis. Microscopic examination revealed a small ro und cell tumor that immunohistochemical studies (including staining fo r the highly restricted surface antigen p30/32(MIC2)) and ultrastructu ral studies indicated was an extraosseous Ewing's sarcoma (EES)/primit ive neuroectodermal tumor (PNET). This diagnosis was established by de tection of EWS/ERG fusion transcript through reverse transcription pol ymerase chain reaction (RT-PCR) with nested primers. Full body compute d tomography failed to detect any extrauterine tumor, and the patient is clinically free of disease 18 months after hysterectomy. This case represents the first report of a primary EES/PNET arising in the uteri ne cervix.