AN EVALUATION OF THE MARKERS P53 AND KI-67 FOR THEIR PREDICTIVE VALUEIN PROSTATE-CANCER

Background and Objectives: p53 and Ki-67 are but two markers being eva luated for their predictive value in prostate cancer. The purpose of t his study was to compare p53 and Ki-67 with age, stage, Gleason score, and ploidy for their prognostic abilities in prostate cancer. Methods : Prostate cancer specimens from 134 patients were immunohistochemical ly stained for p53 and Ki-67 expression and differences evaluated by S PSS analysis of variance (ANOVA) methods. The dependent variable was p atient survival and the independent variables were age, stage, Gleason score, and ploidy. Results: In decreasing order of prediction of surv ival were stage (P < 0.001), Gleason score (P < 0.001), age (P = 0.186 9), Ki-67 (P = 0.2284), p53 (P = 0.4282) and ploidy (P = 0.8141). Conc lusion: It is concluded that stage and Gleason score are significant p redictors of survival while p53, Ki-67, age and ploidy are not. (C) 19 98 Wiley-Liss, Inc.