ISOLATION AND CHARACTERIZATION OF AN ANTIFUNGAL ANTIBIOTIC (GR135402)WITH PROTEIN-SYNTHESIS INHIBITION

Authors
KINSMAN OS CHALK PA JACKSON HC MIDDLETON RF SHUTTLEWORTH A RUDD BAM JONES CA NOBLE HM WILDMAN HG DAWSON MJ STYLLI C SIDEBOTTOM PJ LAMONT B LYNN S HAYES MV
Citation
Os. Kinsman et al., ISOLATION AND CHARACTERIZATION OF AN ANTIFUNGAL ANTIBIOTIC (GR135402)WITH PROTEIN-SYNTHESIS INHIBITION, Journal of antibiotics, 51(1), 1998, pp. 41-49
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
51
Issue
1
Year of publication
1998
Pages
41 - 49
Database
ISI
SICI code
0021-8820(1998)51:1<41:IACOAA>2.0.ZU;2-1
Abstract
A novel antifungal antibiotic GR135402 has been isolated from a fermen tation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The spectrum of acti vity included C. albicans and Cryptococcus neoformans but not some oth er Candida species or Aspergillus species. Therapeutic efficacy in a m ouse model of systemic candidosis was attained following parenteral do sing.