SEPARATION OF ENANTIOMERS OF DRUGS BY CAPILLARY ELECTROPHORESIS - V -HYDROXYPROPYL-ALPHA-CYCLODEXTRIN AS CHIRAL SOLVATING AGENT

In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-alpha-cyclodextrin as chir al solvating agent (CSA). A total of 34 drugs out of 86 could be resol ved in this straightforward approach. The number of experiments perfor med under identical conditions allows a correlation of the separation factors alpha(m) with the interaction strengths R-m. As shown for a su bset of 23 drugs, the concentration of the CSA is a crucial parameter for further optimization. (C) 1998 Elsevier Science B.V.