ASSOCIATION BETWEEN VARIANTS OF MAST-CELL CHYMASE GENE AND SERUM IGE LEVELS IN ECZEMA

Authors
MAO XQ SHIRAKAWA T ENOMOTO T SHIMAZU S DAKE Y KITANO H HAGIHARA A HOPKIN JM
Citation
Xq. Mao et al., ASSOCIATION BETWEEN VARIANTS OF MAST-CELL CHYMASE GENE AND SERUM IGE LEVELS IN ECZEMA, Human heredity, 48(1), 1998, pp. 38-41
Citations number
11
Categorie Soggetti
Genetics & Heredity
Journal title
Human heredity → ACNP
ISSN journal
00015652
Volume
48
Issue
1
Year of publication
1998
Pages
38 - 41
Database
ISI
SICI code
0001-5652(1998)48:1<38:ABVOMC>2.0.ZU;2-P
Abstract
851 school children aged at 12-13 years including 145 with eczema were tested for genetic association to a mast cell chymase (MCC) genetic v ariant. MCC genotypes showed a strong association with eczema, but not with asthma and rhinitis. This association is strongest in eczematous children with lower serum total IgE levels, Independent of IgE respon siveness when total serum IgE of less than 500 IU/ml, MCC variants may play an important role in inflammatory skin disorders.