Background and Study Aims: The value of transabdominal and endoscopic
ultrasound (EUS) in detecting normal adrenal glands is not yet establi
shed. The aim of our study was to evaluate whether these techniques ca
n be routinely used to visualize the adrenal glands in patients withou
t suspected adrenal pathology. Patients and Methods: Transabdominal ul
trasound was validated by examination of 10 corpses and was performed
in 80 healthy volunteers (3.5 and 5 MHz). EUS of the left adrenal glan
d was performed in 154 consecutive patients referred for various other
reasons. In 20 patients we attempted to visualize the right adrenal g
land as well. Results: Both adrenal glands were correctly identified i
n all of the 10 corpses once they were opened. In healthy volunteers,
the right adrenal gland was visualized by transabdominal ultrasound in
79/80 patients (99%) and the left adrenal gland in 55/80 patients (69
%). EUS allowed detection of the left adrenal gland in 151/154 patient
s (98%). In three patients EUS failed because of grossly distorted ana
tomy. In 6/20 patients we were also able to detect the right adrenal g
land by EUS, which was obvious in two cases because of incidentalomas.
Conclusion: Visualization of the right adrenal gland is almost always
possible by transabdominal ultrasound, while its detection by EUS is s
uccessful only in some cases. The left gland is more difficult to dete
ct by transabdominal ultrasound, while it can nearly always be seen us
ing EUS. Therefore, a combined transabdominal and endoscopic ultrasono
graphic approach is useful for visualization of the adrenal glands and
may enable diagnosis of even small adrenal masses.