A MURINE TSPY

Sequences homologous to human and bovine TSPY were isolated from M. mu sculus testicular cDNA, and a nearly full-length gene was polymerase c hain reaction (PCR) amplified from mouse genomic DNA. This gene is app arently non-functional. Contrary to the situation encountered in speci es along the primate and artiodactyl lineages, in which TSPY is modera tely repetitive, murine Tspy appears to be single copy. Murine Tspy is located on Yp, i.e. in the same syntenic group as in man. Sequence co mparisons of murine, human and bovine TSPY exons suggest that TSPY bec ame non-functional during rodent evolution.