SINGLE-AGENT THERAPY FOR NONMETASTATIC AND LOW-RISK GESTATIONAL TROPHOBLASTIC DISEASE

OBJECTIVE: To assess the effectiveness of single-agent chemotherapy in the treatment of nonmetastatic and low-risk metastatic gestational tr ophoblastic tumors. STUDY DESIGN: The medical literature wits reviewed concerning single-agent chemotherapy in the treatment of nonmetastati c and low-risk metastatic gestational trophoblastic tumors. RESULTS: M ethotrexate and actinomycin-D have achieved excellent and comparable r emission rates with acceptable levels of toxicity. CONCLUSION: The opt imal single-agent chemotherapy for nonmetastatic and low-risk metastat ic gestational trophoblastic tumors has not yet been identified and ca n be best determined through a prospective, randomized trial.