Hd. Homesley, SINGLE-AGENT THERAPY FOR NONMETASTATIC AND LOW-RISK GESTATIONAL TROPHOBLASTIC DISEASE, Journal of reproductive medicine, 43(1), 1998, pp. 69-74
OBJECTIVE: To assess the effectiveness of single-agent chemotherapy in
the treatment of nonmetastatic and low-risk metastatic gestational tr
ophoblastic tumors. STUDY DESIGN: The medical literature wits reviewed
concerning single-agent chemotherapy in the treatment of nonmetastati
c and low-risk metastatic gestational trophoblastic tumors. RESULTS: M
ethotrexate and actinomycin-D have achieved excellent and comparable r
emission rates with acceptable levels of toxicity. CONCLUSION: The opt
imal single-agent chemotherapy for nonmetastatic and low-risk metastat
ic gestational trophoblastic tumors has not yet been identified and ca
n be best determined through a prospective, randomized trial.