GESTATIONAL TROPHOBLASTIC DISEASE - SUBSEQUENT PREGNANCY OUTCOME, INCLUDING REPEAT MOLAR PREGNANCY

OBJECTIVE: To determine subsequent reproductive outcomes in patients t reated for partial molar pregnancy, complete molar pregnancy and persi stent gestational trophoblastic tumors at the New England Trophoblasti c Disease Center (NETDC) between June 1, 1965, and December 31, 1996. STUDY DESIGN: Questionnaires were mailed to all patients followed at t he NETDC to assess subsequent pregnancy experience. All patients and t heir referring physicians were also requested to inform the NETDC abou t Inter pregnancies. RESULTS: Following partial mole, complete mole an d persistent gestational trophoblastic tumor, our patients had 195, 1, 234 and 504 later pregnancies, respectively. These patients had a late r pregnancy experience comparable to that of the general population. H owever, after having one molar pregnancy, the risk of molar pregnancy in a later conception was about 1%. Twenty-line of our patients had at least two episodes of molar pregnancy; following two episodes of mola r pregnancy, 6 (23.1 %) of 26 later conceptions resulted in another mo lar gestation. CONCLUSION: Patients with partial mole, complete mole a nd persistent gestational trophoblastic tumor can be reassured that in general they can anticipate a normal future reproductive outcome.