He. Jones et al., FAILURE OF IBOGAINE TO PRODUCE PHENCYCLIDINE-LIKE DISCRIMINATIVE STIMULUS EFFECTS IN RATS AND MONKEYS, Pharmacology, biochemistry and behavior, 59(2), 1998, pp. 413-418
The discriminative stimulus properties of ibogaine were investigated i
n rats trained to discriminate phencyclidine (PCP; 2.0 mg/kg, IP) from
saline under a two-lever fixed-ratio (FR) 32 schedule of food reinfor
cement. Ibogaine (5.6-17.6 mg/kg, IP) showed a complete lack of substi
tution. Ibogaine (0.5-4.0 mg/kg, IM) also failed to generalize in rhes
us monkeys trained to discriminate PCP (0.1 mg/kg, IM) from sham injec
tion. Lysergic acid diethylamide (LSD), rested as a reference compound
, produced partial substitution for PCP in rats and occasioned little
responding on the PCP-associated lever in monkeys. These results demon
strate important differences between the behavioral effects of PCP and
other types of hallucinogenic drugs such as LSD and ibogaine and do n
ot support the hypothesis that the affinity of ibogaine for the PCP si
te on N-methyl-D-aspartate (NMDA) receptors plays a major role in its
acute behavioral effects. (C) 1998 Elsevier Science Inc.