FAILURE OF IBOGAINE TO PRODUCE PHENCYCLIDINE-LIKE DISCRIMINATIVE STIMULUS EFFECTS IN RATS AND MONKEYS

Citation
He. Jones et al., FAILURE OF IBOGAINE TO PRODUCE PHENCYCLIDINE-LIKE DISCRIMINATIVE STIMULUS EFFECTS IN RATS AND MONKEYS, Pharmacology, biochemistry and behavior, 59(2), 1998, pp. 413-418
Citations number
35
Categorie Soggetti
Pharmacology & Pharmacy","Behavioral Sciences
ISSN journal
00913057
Volume
59
Issue
2
Year of publication
1998
Pages
413 - 418
Database
ISI
SICI code
0091-3057(1998)59:2<413:FOITPP>2.0.ZU;2-3
Abstract
The discriminative stimulus properties of ibogaine were investigated i n rats trained to discriminate phencyclidine (PCP; 2.0 mg/kg, IP) from saline under a two-lever fixed-ratio (FR) 32 schedule of food reinfor cement. Ibogaine (5.6-17.6 mg/kg, IP) showed a complete lack of substi tution. Ibogaine (0.5-4.0 mg/kg, IM) also failed to generalize in rhes us monkeys trained to discriminate PCP (0.1 mg/kg, IM) from sham injec tion. Lysergic acid diethylamide (LSD), rested as a reference compound , produced partial substitution for PCP in rats and occasioned little responding on the PCP-associated lever in monkeys. These results demon strate important differences between the behavioral effects of PCP and other types of hallucinogenic drugs such as LSD and ibogaine and do n ot support the hypothesis that the affinity of ibogaine for the PCP si te on N-methyl-D-aspartate (NMDA) receptors plays a major role in its acute behavioral effects. (C) 1998 Elsevier Science Inc.