CAPILLARY ELECTROPHORETIC CHIRAL RESOLUTION OF VICINAL DIOLS BY COMPLEXATION WITH BORATE AND CYCLODEXTRIN - COMPARATIVE-STUDIES ON DIFFERENT CYCLODEXTRIN DERIVATIVES

Capillary electrophoretic enantioseparation of compounds containing vi cinal diol groups have been investigated using different beta-cyclodex trin (CD) derivatives and berate as a background electrolyte. Both nat ive beta-CD and several beta-CD derivatives are examined. Chiral recog nition is attributed to both enantioselective inclusion of the analyte into the chiral cavity of the CD and complexation with berate. The in fluence of concentration of the chiral selector, pH, and organic modif iers on the resolution was studied. Four diols were baseline separated . (C) 1997 Wiley-Liss, Inc.