INTERLEUKIN-10 SECRETION AND IMPAIRED EFFECTOR FUNCTION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II-RESTRICTED T-CELLS ANERGIZED IN-VIVO

Citation
J. Buer et al., INTERLEUKIN-10 SECRETION AND IMPAIRED EFFECTOR FUNCTION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II-RESTRICTED T-CELLS ANERGIZED IN-VIVO, The Journal of experimental medicine, 187(2), 1998, pp. 177-183
Citations number
37
Categorie Soggetti
Immunology,"Medicine, Research & Experimental
ISSN journal
00221007
Volume
187
Issue
2
Year of publication
1998
Pages
177 - 183
Database
ISI
SICI code
0022-1007(1998)187:2<177:ISAIEF>2.0.ZU;2-Z
Abstract
Continuous antigenic stimulation in vivo can result in the generation of so-called ''anergic'' CD4(+) or CD8(+) T cells that fail to prolife rate upon antigenic stimulation and fail to develop cytolytic effector functions. Here we show that class II major histocompatibility comple x-restricted T cells specific for influenza hemagglutinin (HA) that be come allergic in mice expressing HA under control of the immunoglobuli n kappa promoter exhibit an impaired effector function in causing diab etes in vivo, as compared to their naive counterparts, when transferre d into immunodeficient recipients expressing HA under the control of t he insulin promoter. Furthermore, HA-specific T cells anergized in viv o contain higher levels of interleukin (IL)-4 RNA (mRNA) than naive an d recently activated T cells with the same specificity and more than a 100-fold higher levels of IL-10 mRNA. The higher expression of the IL -10 gene is also evident at the protein level. These findings raise th e interesting possibility that T cells rendered anergic in vivo have i n fact become regulatory T cells that may influence neighboring immune responses through the release of IL-10.