INHERITANCE OF CYP6D1-MEDIATED PYRETHROID RESISTANCE IN-HOUSE FLY (DIPTERA, MUSCIDAE)

The inheritance of cytochrome P450 monoxygenase-mediated (i.e., CYP6D1 ) resistance in the LPR strain of house fly, Musca domestica L., was i nvestigated by comparing levels of monooxygenase-mediated permethrin r esistance and CYPGD1 messenger RNA in 7 populations of house flies. Re sults indicate that monooxygenase-mediated resistance, and overexpress ion of CYP6D1, in the LPR strain are controlled by an incompletely rec essive trans acting factor(s) on autosome IZ and a nearly completely d ominant sis acting factor(s) on autosome 1. The polygenic nature of CY P6D1-mediated resistance and the relative dominance of the resistance factor(s) on autosome 1 suggests this type of resistance could develop relatively quickly.