DNA REGIONS SUPPORTING HIPPOCALCIN GENE-EXPRESSION IN CELL-LINES

Authors
GRANT AL WISDEN W
Citation
Al. Grant et W. Wisden, DNA REGIONS SUPPORTING HIPPOCALCIN GENE-EXPRESSION IN CELL-LINES, Molecular brain research, 52(2), 1997, pp. 323-325
Citations number
9
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
52
Issue
2
Year of publication
1997
Pages
323 - 325
Database
ISI
SICI code
0169-328X(1997)52:2<323:DRSHGI>2.0.ZU;2-#
Abstract
The rat hippocalcin gene -3.2 to +0.6 kb region activates reporter gen e expression in the NG108-15 and PC12 neuronal cell lines, but not in NIH3T3 or HEK-293 cells. Three fragments (-3.2 to -2.6, -2.6 to -2.3 a nd -2.3 to -1.8 kb) weakly activate transcription, and '-1.8 to -1.5' kb is a strong activator. Thus cell type-specific expression of the ra t hippocalcin gene is regulated by distributed elements in the -3.2 to -1.5 kb region. (C) 1997 Elsevier Science B.V.