G. Valle et al., A BETA-LACTAMASE BELONGING TO GROUP 2E FROM ORAL CLINICAL ISOLATES OFPREVOTELLA-INTERMEDIA, FEMS microbiology letters, 158(2), 1998, pp. 191-194
A beta-lactamase in oral clinical isolates of Prevotella intermedia th
at hydrolyzed cefuroxime and cephalothin with rates of 600 and 53.3 re
spectively, relative to that for cephaloridine (100), was characterize
d as a 2e-cephalosporinase. Inhibition was observed by clavulanic acid
(IC50 0.72 mu M), tazobactam (IC50 0.21 mu M) and sulbactam (IC50 0.0
7 mu M) and was not inhibited by cloxacillin, EDTA, NaCl or p-CMB. The
pI and pH optima were 4.7 and 5.4, respectively. (C) 1998 Federation
of European Microbiological Societies. Published by Elsevier Science B
.V.