Forty-three wild rats (Rattus norvegicus) trapped in Milan (Italy) wer
e examined for gastric spiral bacteria and to evaluate associated hist
ological lesions. Spiral bacteria were histologically detected in the
stomach of 10 rats (23%). The morphological features of these microorg
anisms, observed using both light and electron microscopy, correspond
to those of Helicobacter heilmannii. Mild gastritis characterized by f
ocal lymphoplasmacytic infiltration of the lamina propria was observed
in six rats with gastric spiral bacteria. Our findings suggest a caus
al role of these bacteria in inducing a gastric inflammatory response.