REPORT OF OPTIC DISC EDEMA IN GROWTH-HORMONE INSENSITIVE PATIENTS AFTER TREATMENT WITH INSULIN-LIKE GROWTH-FACTOR-I

Intracranial hypertension with papilledema has recently been reported with growth hormone administration, We present the case of a 14 year o ld female with growth hormone insensitivity syndrome (GHIS), who devel oped optic disc edema (ODE) within 30 days of the initiation of therap y with recombinant IGF-l (insulin-like growth factor 1) (120 mu g/kg B ID), Symptoms may he intermittent, and thereby unreliable indicators o f ODE, At least 5/131 patients with GHIS who have received IGF-I have developed this condition. Because of the high risk for developing ODE in this patient population, serial funduscopic examination is warrante d for children receiving IDF-I.