PRIMARY INFECTION BY HUMAN PARVOVIRUS B19 AND COLD AGGLUTININS

lntroduction: Parvovirus B19 infection is frequent. Primary infection leads to diverse skin manifestations including the recently described gloves-and-socks papulopurpura. Case report: A patient presented with a papulopurpuric eruption on the nose, hands, feet and perineum with c heilitis and high-grade fever. Parvovirus B19 serology showed characte ristic IgG on the 15th day after the initial eruption demonstrating th e seroconversion. Cold agglutinins were positive during the eruption a nd negative after regression. Discussion: The gloves-and-socks papulop urpura syndrome was initially described in 1990. Since that time 20 ca ses have been reported. In 7 cases, primary parvovirus B19 infection w as proven and viral infections were suspected in the others (measles, coxsackie B6, hepatitis B, Epstein-Barr virus). Our case evidenced her e to undescribed skin manifestations and the development of cold agglu tinins. The presence of cold agglutinins at eruption could explain the acral localizations observed in this syndrome.