ANTIMICROBIAL RESISTANCE OF SALMONELLA-ENTERICA TYPHIMURIUM DT104 ISOLATES AND INVESTIGATION OF STRAINS WITH TRANSFERABLE APRAMYCIN RESISTANCE

An examination of salmonella isolates collected by the Scottish Agricu ltural College Veterinary Services Division from April 1994 to May 199 5 was conducted to determine the extent to which Salmonella enterica s erotype Typhimurium phage type 104 (DT104) occurred and to investigate the antimicrobial resistance patterns of isolates. Typhimurium DT104 was the predominant salmonella and was isolated from nine species of a nimal. All isolates of this phage type possessed resistance to at leas t one antimicrobial and 98 % of the isolates were resistant to multipl e antimicrobials with R-type ACTSp the predominant resistance pattern. Various other resistance patterns were identified and transferable re sistance to the veterinary aminoglycoside antimicrobial apramycin was demonstrated in three strains. A retrospective study for gentamicin re sistance in isolates from the Scottish Salmonella Reference Laboratory collection revealed a human isolate of Typhimurium DT104 resistant to gentamicin but sensitive to apramycin and a bovine isolate with apram ycin and gentamicin resistance.