CHROMOSOME ENDS - ALL THE SAME UNDER THEIR CAPS

The recent characterisation of subtelomeric regions from a variety of organisms from yeast to man has led to the realisation that all chromo some ends are similar in structure although maintenance of the terminu s varies. The mosaic of repeats and proteins associated with telomeres has an architectural role which divides the genome into two domains, allowing for the adaptive use of the region as well as the evolution o f non-telomerase-mediated telomere maintenance. (C) Current Biology Lt d ISSN 0959-437X.