SELEX AND THE EVOLUTION OF GENOMES

Authors
GOLD L SINGER B HE YY BRODY E
Citation
L. Gold et al., SELEX AND THE EVOLUTION OF GENOMES, Current opinion in genetics & development, 7(6), 1997, pp. 848-851
Citations number
27
Journal title
Current opinion in genetics & development → ACNP
ISSN journal
0959437X
Volume
7
Issue
6
Year of publication
1997
Pages
848 - 851
Database
ISI
SICI code
0959-437X(1997)7:6<848:SATEOG>2.0.ZU;2-Y
Abstract
The interrupted genome structures of complex multicellular organisms h ave most likely changed the evolution of the regulation of metabolism and development. Wasted intron sequences make regulation of gene expre ssion in (for example) mammals appear to be unnecessarily complicated. The recent discoveries that globular RNA molecules are very much like the antigen-combining sites of antibodies suggest that intronic RNA m ay be used to help solve the problems raised by this complexity. (C) C urrent Biology Ltd ISSN 0959-437X.