Purpose: The use of metal oxide-silicon field effect transistors (MOSF
ETs) as clinical dosimeters is demonstrated for a number of patients w
ith targets at different clinical sites. Methods and Materials: Commer
cially available MOSFETs were characterized for energy response, angul
ar dependency of response, and effect of accumulated dose on sensitivi
ty and some inherent properties of MOSFETs. The doses determined both
by thermoluminescence dosimetry (TLD) and MOSFETs in clinical situatio
n were evaluated and compared to expected doses determined by calculat
ion, Results: It was observed that a standard calibration of 0.01 Gy/m
V gave MOSFET determined doses which agreed with expected doses to wit
hin 5% at the 95% confidence limit for photon beams from 6 to 25 MV an
d electron beams from 5 to 14 MeV. An energy-dependent variation in re
sponse of up to 28% was observed between two orientations of a MOSFET,
The MOSFET doses compared very well with the doses estimated by TLDs,
and the patients tolerated MOSFETs very well, A standard deviation of
3.9% between expected dose and MOSFET determined dose was observed, w
hile for TLDs the standard deviation was 5.1%. The advantages and disa
dvantages of using MOSFETs for clinical dosimetry are discussed in det
ail, Conclusion: It was concluded that MOSFETs can be used as clinical
dosimeters and can be a good alternative to TLDs, However, they have
limitations under certain clinical situations, (C) 1997 Elsevier Scien
ce Inc.