CYTOGENETIC ANALYSIS OF SUBCUTANEOUS ANGIOLIPOMA - FURTHER EVIDENCE SUPPORTING ITS DIFFERENCE FROM ORDINARY PURE LIPOMAS - A REPORT OF THE CHAMP STUDY-GROUP
R. Sciot et al., CYTOGENETIC ANALYSIS OF SUBCUTANEOUS ANGIOLIPOMA - FURTHER EVIDENCE SUPPORTING ITS DIFFERENCE FROM ORDINARY PURE LIPOMAS - A REPORT OF THE CHAMP STUDY-GROUP, The American journal of surgical pathology, 21(4), 1997, pp. 441-444
Subcutaneous angiolipomas are benign soft-tissue lesions consisting of
two mesenchymal elements (i.e., adipose tissue and blood vessels) and
having distinct clinical features. They usually are multiple, with an
obvious male predominance, and hereditary occurrence has been describ
ed. Twenty subcutaneous angiolipomas from 10 patients with typical cli
nical and morphologic features were reviewed. All lesions had a normal
karyotype. This finding is in striking contrast with ordinary lipomas
, spindle-cell and pleomorphic lipomas, lipoblastomas, and hibernomas:
most of which have characteristic clonal chromosomal aberrations. The
normal karyotype of subcutaneous angiolipoma as well as its distinct
clinical and morphologic features suggest a different pathogenesis fro
m pure lipomas.