From the leaves of Buxus sempervirens has been isolated, in addition t
o known alkaloids, a new alkaloid, spirofornabuxine (1), and its struc
ture was determined by NMR spectroscopic analysis. This new alkaloid c
an be considered as the first member of a new group of steroidal deriv
atives, the spirobuxus alkaloids. Its implication in the biosynthesis
of other Buxus alkaloids is discussed. (C) 1997 Published by Elsevier
Science Ltd.