A HIGH-YIELD SYNTHESIS OF DEOXY-2-FLUOROINOSINE AND ITS INCORPORATIONINTO OLIGONUCLEOTIDES

Authors
ADIB A POTIER PF DORONINA S HUC I BEHR JP
Citation
A. Adib et al., A HIGH-YIELD SYNTHESIS OF DEOXY-2-FLUOROINOSINE AND ITS INCORPORATIONINTO OLIGONUCLEOTIDES, Tetrahedron letters, 38(17), 1997, pp. 2989-2992
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
17
Year of publication
1997
Pages
2989 - 2992
Database
ISI
SICI code
0040-4039(1997)38:17<2989:AHSODA>2.0.ZU;2-D
Abstract
An improved synthesis of the deoxy-2-fluoroinosine nucleoside is descr ibed, that makes use of mild fluorination (polyvinylpyridinium polyhyd rogenfluoride) and O-silyl deprotection (triethylamine trihydrofluorid e) reactions. The derived dimethoxytrityl-2-fluoroinosine-3'-phosphora midite was incorporated into 10-, 15- and 20- mer oligonucleotides con taining up to 7 non-natural bases. (C) 1997 Published by Elsevier Scie nce Ltd.