PROTECTION AGAINST MYCOBACTERIUM-TUBERCULOSIS INFECTION BY CD8(-CELLSREQUIRES THE PRODUCTION OF GAMMA-INTERFERON() T)

Authors
TASCON RE STAVROPOULOS E LUKACS KV COLSTON MJ
Citation
Re. Tascon et al., PROTECTION AGAINST MYCOBACTERIUM-TUBERCULOSIS INFECTION BY CD8(-CELLSREQUIRES THE PRODUCTION OF GAMMA-INTERFERON() T), Infection and immunity, 66(2), 1998, pp. 830-834
Citations number
32
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
2
Year of publication
1998
Pages
830 - 834
Database
ISI
SICI code
0019-9567(1998)66:2<830:PAMIBC>2.0.ZU;2-V
Abstract
The role of CD8 T cells in controlling Mycobacterium tuberculosis infe ctions in mice was confirmed by comparing the levels of growth of the organism in control, major histocompatibility complex: class Ii knocko ut, and athymic mice and by transferring T-cell populations into athym ic mice. By using donor mice which were incapable of making gamma inte rferon (IFN-gamma), it was shown that IFN-gamma production was essenti al for CD8 cell mediation of protective immunity against M. tuberculos is.