CYTOKINES IN THE MODULATION OF EOSINOPHILIA

In this review we discuss our recently results showing interleukin 5 ( IL-5) involvement in eosinophil migration and in the maintenance of eo sinophilia in blood, bone marrow, lung and peritoneal cavity, in a vis ceral larva migrans syndrome model using guinea-pigs infected with Tox ocara canis. We also describe the sequential release of TNF-alpha and IL-8 during the course of infection, and the interaction between these cytokines and IL-5 during infection. Finally we propose a new biologi cal role for IL-5, at least ill our model, as a modulator of IL-8 rele ase and secretion.