An overview is given on the wealth of data recently provided by large
mm-wave radiotelescopes on AGE stars, planetary nebulae (PNe), and tra
nsition objects. The observations reveal that there is an observable c
hemical evolution in the neutral gas as a star evolves beyond the AGE,
through the proto-PN and PN phases. Significant changes in the abunda
nces of some key molecules (such as CS, CN: HCO+, HCN, and HC3N) take
place during the fast evolution of the envelopes. Chemistry can thus b
e used as a rough clock to date the evolutionary stage of post-AGE env
elopes and proto-PN objects. However, once the PN is formed, the obser
ved abundances in the molecular clumps of the envelope remain relative
ly constant. The chemical evolution of the molecular envelopes likely
occurs through the development of photon-dominated regions produced by
the ultraviolet held of the central star. The main chemical processes
which likely control the evolution are also reviewed.