Because pulmonary embolism is often silent, simple clinical procedures
are desirable to identify patients with a low to intermediate probabi
lity of pulmonary embolism. Among 19467 patients managed under general
anesthesia, we had one bile tract surgery case and three neurosurgica
l cases whose silent pulmonary embolism was initially suggested by an
increase in the arterial to end-tidal CO2 gradient (from 17 to 27 mmHg
) after general anesthesia was induced or their trachea was intubated.
During the preoperative assessment, the patients presented no clinica
l manifestations suggestive of pulmonary embolism. Our initial diagnos
is was confirmed by scintigraphy and/or angiography done immediately a
fter the operations. Because capnometry has been shown to be applicabl
e to non-intubated, spontaneously breathing patients, we suggest that
measuring the gradient may serve as an additional method for unmasking
silent pulmonary embolism in patients at risk or with disturbed consc
iousness, whether they are scheduled for operations or not. (C) 1997 T
ohoku University Medical Press.