RENAL-SPARING THERAPY IN CASE OF WILMS-TU MOR

Wilms-Tumor is the most common renal malignancy in childhood. Improved therapeutic strategies as well as interdisciplinary cooperation betwe en surgeon, radiotherapist and paediatric oncologist have significantl y improved the survival rates. Tumor nephrectomy, an important part of therapy, may change the function of the contralateral kidney, resulti ng in renal failure and the need for dialysis or renal tansplantation. Between 1967 and 1996, 15 patients with Wilms-Tumor (bilateral synchr onous: n = 10; bilateral metachronous: n = 3; unilateral disease: n = 2) were treated with renal-sparing therapy (chemotherapy, radiotherapy and enucleative surgery or partial nephrectomy). In a follow-up of 12 months to 21 years, 12 of 15 patients have been free of tumor and rel apse.