7-dihydro-5H-dibenzo[a,c]cycloheptene-6-carboxylic acid ethyl ester H-
beta(2)-Bip-OEt 1a and its 1,1'-binaphthyl optically pure analog (R) H
-beta(2)-Bin-OEt 2a have been readily synthesized by bis-alkylation of
ethyl cyanoacetate with 2,2'-bis-(bromomethyl)-1,1'-diphenyl or optic
ally pure (+)-(R)-2,2'-bis-(bromomethyl)-1,1'-binaphthyl, followed by
NaBH4/CoCl2 selective reduction of the cyano group. The N-Boc protecte
d derivatives and short peptides of these novel aminoacids have also b
een prepared (C) 1998 Elsevier Science Ltd. All rights reserved.